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KMID : 0352720160400040359
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Journal of Ginseng Research
2016 Volume.40 No. 4 p.359 ~ p.365
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Vasodilator-stimulated phosphoprotein-phosphorylation by ginsenoside Ro inhibits fibrinogen binding to αIIb/β3 in thrombin-induced human platelets
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Shin Jung-Hae
Kwon Hyuk-Woo
Cho Hyun-Jeong
Rhee Man-Hee
Park Hwa-Jin
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Abstract
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Background: Glycoprotein IIb/IIIa (aIIb/b3) is involved in platelet adhesion, and triggers a series of intracellular signaling cascades, leading to platelet shape change, granule secretion, and clot retraction. In this study, we evaluated the effect of ginsenoside Ro (G-Ro) on the binding of fibrinogen to aIIb/b3.
Methods: We investigated the effect of G-Ro on regulation of signaling molecules affecting the binding of fibrinogen to aIIb/b3, and its final reaction, clot retraction.
Results: We found that G-Ro dose-dependently inhibited thrombin-induced platelet aggregation and attenuated the binding of fibrinogen to aIIb/b3 by phosphorylating cyclic adenosine monophosphate (cAMP)-dependently vasodilator-stimulated phosphoprotein (VASP; Ser157). In addition, G-Ro strongly abrogated the clot retraction reflecting the intensification of thrombus.
Conclusion: We demonstrate that G-Ro is a beneficial novel compound inhibiting aIIb/b3-mediated fibrinogen binding, and may prevent platelet aggregation-mediated thrombotic disease.
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KEYWORD
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cAMP, clot retraction, ginsenoside Ro, fibrinogen binding, VASP (Ser157)
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